"The two leads, Burt (Jon Krasinski) and Verona (Maya Rudolph), are excellent in their portrayals of a young man thrilled he is to become a father and a woman feeling irritable and uncomfortable during her pregnancy. 
The picture becomes a road flick when the unmarried couple decides to drive across the country to visit relatives and look for a place to live. 
Another person Verona and Burt visit is LN (Maggie Gyllenhaal), a disliked professor at a Madison, Wisconsin, university. 
(An aside. In real life, Maggie Gyllenhaal lives with her daughter and husband, Peter Sarsgaard, in the Village, where I live. 
Reese Witherspoon and Jake Gyllenhaal shopping in Soho, on 6th June, 2009.Further, before going to see this movie, I had lunch at Balthazar in Soho, and in walked her brother, Jake Gyllenhaal, with his lady friend, Reese Witherspoon"
Source: www.thevillager.com